Products Categories
    Product Certification&
    Enterprise Certification

  • Mr.pei
    Tel: +86-22-23754520

  • Mobile:+86 15076683720
  • Tel:+86-22-23754520
  • Fax:+86-22-23754520
  • Province/state:Tianjin
  • City:Tianjin
  • Street:Tianjin hi tech development in Xiqing District 2 Road No. 2 Building No. 5 414
  • MaxCard:
Home > Products >  CCG-1423

CCG-1423 CAS NO.285986-88-1

  • FOB Price: USD: /Kilogram Get Latest Price
  • Min.Order: 1 Gram
  • Payment Terms: T/T
  • Available Specifications:

    reagent grade(1-10)Kilogram

  • Product Details

Keywords

  • CCG-1423 Structure
  • CCG1423 supplier
  • CCG 1423

Quick Details

  • ProName: CCG-1423
  • CasNo: 285986-88-1
  • Molecular Formula: C18H13ClF6N2O3
  • Appearance: Solid powder
  • Application: Use as research only
  • DeliveryTime: in stock
  • PackAge: according to the clients requirement
  • Port: Tianjin
  • ProductionCapacity: 10 Kilogram/Month
  • Purity: More than 98%
  • Storage: Store at -20°C
  • Transportation: by sea or by air
  • LimitNum: 1 Gram
  • Valid Period: 2 years

Superiority

In stock ,>98% purity with low price. If you need HNMR\HPLC,please contact us! 

1.we are direct manufacturer and we have 7 years experience in this aera.
2.we can provide competitive price for every customer and guarantee the quality of our goods.
3.Specials are possible when client's order is big enough, including the discount policy;
4.we promise we will return your money if our product don't have effect.
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
6. Our customers may buy our products again after they use our sample.

Details

CCG-1423 is a small-molecule inhibitor of RhoA transcriptional signaling. CCG-1423 displays activity in several in vitro cancer cell functional assays. CCG-1423 potently (<1 mumol/L) inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells, and whereas it inhibits the growth of RhoC-overexpressing melanoma lines (A375M2 and SK-Mel-147) at nanomolar concentrations, it is less active on related lines (A375 and SK-Mel-28) that express lower levels of Rho. Similarly, CCG-1423 selectively stimulates apoptosis of the metastasis-prone, RhoC-overexpressing melanoma cell line (A375M2) compared with the parental cell line (A375). CCG-1423 inhibited Rho-dependent invasion by PC-3 prostate cancer cells, whereas it did not affect the Galpha(i)-dependent invasion by the SKOV-3 ovarian cancer cell line. Thus, based on its profile, CCG-1423 is a promising lead compound for the development of novel pharmacologic tools to disrupt transcriptional responses of the Rho pathway in cancer. (Mol Cancer Ther. 2007 Aug;6(8):2249-60.).

 

Tianjin Kailiqi Biopharma Technology Co., Ltd, is a professional manufacturer specialized in the production and distribution of active pharmaceutical ingredients and intermediates. Our company has strong R&D ability and production experience to provide the customers new APIs. We specialize in developing innovative processes for the synthesis of a wide range of products. We also undertake custom synthesis and contract manufacturing.if you are interest in,pls contact with me,we also have Lab,specifical in some hard synthesis.

Other products of this supplier

lookchemhot product CAS New CAS Cas Database Article Data Chemical Catalog