TMP-195 CAS NO.1314891-22-9

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TMP-195
TMP195
N-(2-methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

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ProName: TMP-195
CasNo: 1314891-22-9
Molecular Formula: C23H19F3N4O3
Application: Use as research only
DeliveryTime: on depending
PackAge: 1g,5g,10g,100g,1000g,
Port: Tianjin
ProductionCapacity: Metric Ton/Day
Purity: More than 98%
Storage: Store at -20°C
Transportation: by sea or by air
LimitNum: 0 Metric Ton

Superiority

TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC₅₀ of 300 nM

Best quality & Attractive price & Professional service;

Kailiqi Biopharma is leading by professional teams for years and is qualified as the superior supplier of Merck, Novartis, Mitsui Chemicals.

Kailiqi Biopharma develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED materials & OLED intermediates and other fine chemicals.

Kailiqi Biopharma also wants to be the STRATEGIC PARTNER for more and more pharma and chemical companies with our below Superiority:
1.Direct manufacturer and have several years experience in this aera.
2.Provide competitive price for every customer and guarantee the quality of our goods.
3.Specials are possible when client's order is big enough, including the discount policy;
4.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
5. Our customers may buy our products again after they use our sample.

Our value:
1. Customer Satisfaction is our priority and guarantee for the future.
2. We co-develop products and projects with our partners.
3. We are passionate about the success of our projects.

Details

TMP195 blocks the accumulation of CCL2 protein in the supernatants of monocyte-derived macrophage differentiation cultures. TMP195 significantly increases the amount of CCL1 protein secreted by the monocytes compared to vehicle group. In the transcriptional profiling data from the PHA-stimulated PBMC experiments, CCL2 and CCL1 are respectively down- or upregulated by TMP195^[1]. TMP195 occupies the acetyllysine-binding site of class IIa HDACs. TMP195 competes against binding of HDAC7 to a variety of side-chain modifications on the same peptide backbone, despite no interference with the activity of other acetyllysine reader proteins BRD4 (IC₅₀>50 μM)^[2].

[1]. Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.

[2]. Guerriero JL, et al. Class IIa HDAC inhibition reduces breast tumors and metastases through anti-tumor macrophages. Nature. 2017 Mar 16;543(7645):428-432.

Kailiqi Biopharma is a professional manufacturer specialized in the production and distribution of active pharmaceutical ingredients and intermediates.. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED materials & OLED intermediates and other fine chemicals. Kailiqi Biopharma consists a team of professional analytical department complete QC&QA under strict SOPs, experienced sale and after-sale service, efficient logistic support.
We are good at technology：
1.High pressure hydrogenation
2. Low temperature reactions (-90°C)
3. Chiral compounds by asymmetric synthesis (either chiral auxiliaries or catalysts)
4. Small molecule biologics (e.g. non-natural amino acids, fluorinated amino acids)
5. Green reactions (ionic liquids/fluorous chemistry)

We could give you:
1. Best quality in your requirement
2. Competitive price in China market
3. Mature Technical support
4. Professional logistic support

All we want is win-win business. Send us your inquiries, you will get it!

TMP-195 CAS NO.1314891-22-9

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